Fixing Adobe Error 53 on Mac Office (Word/Powerpoint)

Summary

This article explains how to fix the annoying "Run time error 53" on Mac when opening Word, Powerpoint documents.

Body

With finder open, click Go->Go to folder

Manually type in 

/Library/Application Support/Microsoft/Office365/User Content.localized/Startup/

Within that folder, should be folder for Word, Powerpoint, etc.

Delete any files within each Word,Powerpoint folder.

Quit and Reopen a document to verify error is gone.

Plan B:  
Delete the /Startup Folder in /Library/Application Support/Microsoft/Office365/User Content.localized and reboot.
Test again.

Details

Details

Article ID: 26907
Created
Tue 10/28/25 11:56 AM
Modified
Fri 12/19/25 2:52 PM